Klondike is challenging because many cards are hidden in the tableau, and the order of cards in the stock also matters. In most situations, the best move is the one that uncovers a hidden card.
Be thoughtful about moving cards to the foundations. Twos are almost always safe to play immediately, but some low cards may still be useful in the tableau. For example, moving both red threes too early can leave you without a place to move black twos later.
Try not to let one tableau pile grow much larger than the others. Balanced columns usually give you more flexibility and make it easier to free hidden cards.